InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.71665

Summary

InnateDB Gene

IDBG-633572.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.71665

Gene Name

homeobox protein Hox-A10

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000040082

Encoded Proteins

IDBP-685288

homeobox A10

IDBP-685290

homeobox A10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000253293:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:69322975-69326738

Strand

Forward strand

Band

Transcripts

ENSBTAT00000063132	ENSBTAP00000055322
ENSBTAT00000056468	ENSBTAP00000051506

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030326	embryonic limb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060065	uterus development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Homo sapiens

Gene ID

Gene Order

ENSMUSG00000000938

View Gene Order

ENSG00000253293

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.71665

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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