Version 5.4
| Bos taurus Gene: BT.49346 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-633668.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | BT.49346 | ||||||||
| Gene Name | tumor necrosis factor receptor superfamily member 9 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000003313 | ||||||||
| Encoded Proteins |
tumor necrosis factor receptor superfamily member 9
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] The expression of the ligand-receptor pair TNFSF9-TNFRSF9 on monocytes and natural killer cells is induced by Mycobacterium tuberculosis. Blockage of the TNFRSF9 pathway enhanced the level of IFNG and TNFA producing lymphocytes against the pathogen.
[Mus musculus] The expression of ligand-receptor pair Tnfsf9-Tnfrsf9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the Tnfrsf9 pathway enhanced the level of Ifng and Tnfa producing lymphocytes against the pathogen. (Demonstrated in human)
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049249:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 16:46288366-46306428 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
Cytokine-cytokine receptor interaction pathway
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| INOH | |||||||||
| PID NCI |
Downstream signaling in naïve CD8+ T cells
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MXW8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 520341 | ||||||||
| UniGene | Bt.49346 | ||||||||
| RefSeq | NM_001035336 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02043040 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 520341 | ||||||||