Version 5.4
Mus musculus Gene: Tnfrsf9
Summary
InnateDB Gene IDBG-205902.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf9
Gene Name tumor necrosis factor receptor superfamily, member 9
Synonyms 4-1BB; A930040I11Rik; AA408498; AI325004; Cd137; CDw137; ILA; Ly63
Species Mus musculus
Ensembl Gene ENSMUSG00000028965
Encoded Proteins
IDBP-205904
tumor necrosis factor receptor superfamily, member 9
IDBP-205906
tumor necrosis factor receptor superfamily, member 9
IDBP-270381
tumor necrosis factor receptor superfamily, member 9
IDBP-270383
tumor necrosis factor receptor superfamily, member 9
IDBP-274560
tumor necrosis factor receptor superfamily, member 9
IDBP-536744
tumor necrosis factor receptor superfamily, member 9
IDBP-541440
tumor necrosis factor receptor superfamily, member 9
IDBP-531838
tumor necrosis factor receptor superfamily, member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21747409
The expression of ligand-receptor pair Tnfsf9-Tnfrsf9 on monocytes and NK cells is induced by Mycobacterium tuberculosis. Blockage of the Tnfrsf9 pathway enhanced the level of Ifng and Tnfa producing lymphocytes against the pathogen. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21747409
[Homo sapiens] The expression of the ligand-receptor pair TNFSF9-TNFRSF9 on monocytes and natural killer cells is induced by Mycobacterium tuberculosis. Blockage of the TNFRSF9 pathway enhanced the level of IFNG and TNFA producing lymphocytes against the pathogen.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049249:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:150914562-150946102
Strand Forward strand
Band E2
Transcripts
ENSMUST00000030808 ENSMUSP00000030808
ENSMUST00000060901 ENSMUSP00000059684
ENSMUST00000105672 ENSMUSP00000101297
ENSMUST00000105671 ENSMUSP00000101296
ENSMUST00000116257 ENSMUSP00000111961
ENSMUST00000135169 ENSMUSP00000120761
ENSMUST00000139826 ENSMUSP00000117860
ENSMUST00000146133
ENSMUST00000126707 ENSMUSP00000122917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
Biological Process
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0070207 protein homotrimerization
GO:2001180 negative regulation of interleukin-10 secretion
GO:2001183 negative regulation of interleukin-12 secretion
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000049249
View Gene Order
ENSBTAG00000003313
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
Cross-References
SwissProt
TrEMBL A2A886 A2A887
UniProt Splice Variant
Entrez Gene 21942
UniGene Mm.244187 Mm.416247 Mm.416252
RefSeq NM_001077508 NM_001077509 NM_011612
OMIM
CCDS CCDS18976 CCDS38980
HPRD
IMGT
MGI ID MGI:1101059
MGI Symbol Tnfrsf9
EMBL AL607084 AL607143
GenPept
RNA Seq Atlas 21942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca