Version 5.4
Bos taurus Gene: COL4A1
Summary
InnateDB Gene IDBG-633705.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL4A1
Gene Name Collagen alpha-1(IV) chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012849
Encoded Proteins
IDBP-685452
Collagen alpha-1(IV) chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187498:
This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:88876125-89009422
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035335 ENSBTAP00000035211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0048407 platelet-derived growth factor binding
Biological Process
GO:0001569 patterning of blood vessels
GO:0007420 brain development
GO:0007528 neuromuscular junction development
GO:0048514 blood vessel morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0061333 renal tubule morphogenesis
GO:0071230 cellular response to amino acid stimulus
GO:0071711 basement membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000187498
View Gene Order
ENSMUSG00000031502
View Gene Order
Pathways
NETPATH
REACTOME
REACT_206550
Collagen formation pathway
REACT_219927
Non-integrin membrane-ECM interactions pathway
REACT_217282
NCAM signaling for neurite out-growth pathway
REACT_215758
Collagen biosynthesis and modifying enzymes pathway
REACT_206044
Laminin interactions pathway
REACT_204365
Signaling by PDGF pathway
REACT_223425
Extracellular matrix organization pathway
REACT_202514
NCAM1 interactions pathway
REACT_222620
Collagen degradation pathway
REACT_201925
Degradation of the extracellular matrix pathway
REACT_226104
Assembly of collagen fibrils and other multimeric structures pathway
REACT_209041
Scavenging by Class A Receptors pathway
REACT_215983
Anchoring fibril formation pathway
REACT_214353
Signal Transduction pathway
REACT_203140
Axon guidance pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_207047
Integrin cell surface interactions pathway
REACT_222217
ECM proteoglycans pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_16888
Signaling by PDGF pathway
REACT_150268
Anchoring fibril formation pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_18266
Axon guidance pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_120729
Collagen formation pathway
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_236183
NCAM1 interactions pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_196595
Anchoring fibril formation pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_202342
Laminin interactions pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188257
Signal Transduction pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa04974
Protein digestion and absorption pathway
mmu04512
ECM-receptor interaction pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05200
Pathways in cancer pathway
mmu05146
Amoebiasis pathway
mmu04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt Q7SIB2
TrEMBL G1K238 Q7M2X4
UniProt Splice Variant
Entrez Gene 282191
UniGene Bt.32410
RefSeq NM_001166511 XM_005213978 XM_005213979
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02034907 DAAA02034908 DAAA02034909
GenPept
RNA Seq Atlas 282191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca