InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: COL4A1

Summary

InnateDB Protein

IDBP-685452.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL4A1

Protein Name

Collagen alpha-1(IV) chain

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035211

InnateDB Gene

IDBG-633705 (COL4A1)

Protein Structure

UniProt Annotation

Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0048407	platelet-derived growth factor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0007420	brain development
GO:0007528	neuromuscular junction development
GO:0048514	blood vessel morphogenesis
GO:0061304	retinal blood vessel morphogenesis
GO:0061333	renal tubule morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071711	basement membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0005587	collagen type IV trimer
GO:0005604	basement membrane