InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACD

Summary

InnateDB Gene

IDBG-633735.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACD

Gene Name

ACD protein; Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018903

Encoded Proteins

IDBP-685515

ACD proteinUncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102977:
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:35327418-35333286

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025159

ENSBTAP00000025159

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070182	DNA polymerase binding

Biological Process

GO:0000723	telomere maintenance
GO:0001501	skeletal system development
GO:0001655	urogenital system development
GO:0006886	intracellular protein transport
GO:0016233	telomere capping
GO:0030326	embryonic limb morphogenesis
GO:0031848	protection from non-homologous end joining at telomere
GO:0032202	telomere assembly
GO:0032211	negative regulation of telomere maintenance via telomerase
GO:0035282	segmentation
GO:0051973	positive regulation of telomerase activity
GO:0060381	positive regulation of single-stranded telomeric DNA binding
GO:0070198	protein localization to chromosome, telomeric region