InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64988

Summary

InnateDB Gene

IDBG-633807.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64988

Gene Name

activated CDC42 kinase 1

Synonyms

ACK; ACK1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021364

Encoded Proteins

IDBP-685566

activated CDC42 kinase 1

IDBP-685571

activated CDC42 kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061938:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:71207395-71230157

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028482	ENSBTAP00000028482
ENSBTAT00000046471	ENSBTAP00000043771

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369	regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0070436	Grb2-EGFR complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000061938

View Gene Order

ENSMUSG00000022791

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

cdc42_pathway

CDC42 signaling events

Cross-References

SwissProt

TrEMBL

F6PN06

UniProt Splice Variant

Entrez Gene

280710

UniGene

Bt.64988

RefSeq

NM_173885

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02001684

GenPept

RNA Seq Atlas

280710