InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.64988

Summary

InnateDB Protein

IDBP-685571.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64988

Protein Name

activated CDC42 kinase 1

Synonyms

ACK; ACK1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043771

InnateDB Gene

IDBG-633807 (BT.64988)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369	regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0070436	Grb2-EGFR complex

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR013761 Sterile alpha motif/pointed domain
IPR015116 Cdc42 binding domain like
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021619 EGFR receptor inhibitor Mig-6

PFAM