Version 5.4
Bos taurus Gene: DERL2
Summary
InnateDB Gene IDBG-633968.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DERL2
Gene Name derlin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020431
Encoded Proteins
IDBP-685710
Der1-like domain family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072849:
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:26683195-26691719
Strand Forward strand
Band
Transcripts
ENSBTAT00000045508 ENSBTAP00000042889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001967 suckling behavior
GO:0008284 positive regulation of cell proliferation
GO:0030307 positive regulation of cell growth
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0030970 retrograde protein transport, ER to cytosol
Cellular Component
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072849
View Gene Order
ENSMUSG00000018442
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_233316
Hedgehog ligand biogenesis pathway
REACT_248271
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_232469
Hh ligand biogenesis disease pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001035059 XM_005220202
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca