InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: XPA

Summary

InnateDB Gene

IDBG-633992.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPA

Gene Name

DNA repair protein complementing XP-A cells

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009734

Encoded Proteins

IDBP-685735

xeroderma pigmentosum, complementation group A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136936:
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:63338261-63365679

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012834

ENSBTAP00000012834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006979	response to oxidative stress
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0009636	response to toxic substance
GO:0035264	multicellular organism growth