Version 5.4
Bos taurus Gene: CSNK2B
Summary
InnateDB Gene IDBG-634037.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK2B
Gene Name Casein kinase II subunit beta
Synonyms CSKN2B
Species Bos taurus
Ensembl Gene ENSBTAG00000008837
Encoded Proteins
IDBP-685785
Casein kinase II subunit beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204435:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008]
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27447511-27451477
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045545 ENSBTAP00000042926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 207 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 207 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016301 kinase activity
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016055 Wnt signaling pathway
GO:0016310 phosphorylation
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0033211 adiponectin-activated signaling pathway
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045859 regulation of protein kinase activity
GO:0061154 endothelial tube morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005956 protein kinase CK2 complex
GO:0031519 PcG protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204435
View Gene Order
ENSMUSG00000024387
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_216366
M Phase pathway
REACT_215526
L1CAM interactions pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_218900
Condensation of Prometaphase Chromosomes pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_216684
Signal transduction by L1 pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214934
Cell Cycle pathway
REACT_214353
Signal Transduction pathway
REACT_203140
Axon guidance pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_203101
Mitotic Prometaphase pathway
REACT_209577
WNT mediated activation of DVL pathway
REACT_207087
Disease pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_682
Mitotic Prometaphase pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_200668
WNT mediated activation of DVL pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_261444
Axon guidance pathway
REACT_215461
Signal transduction by L1 pathway
REACT_196632
Condensation of Prometaphase Chromosomes pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_225118
WNT mediated activation of DVL pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04520
Adherens junction pathway
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
mmu04310
Wnt signaling pathway pathway
mmu04520
Adherens junction pathway
INOH
PID NCI
alk1pathway
ALK1 signaling events
Cross-References
SwissProt P67868
TrEMBL N0E640 Q3KUS6
UniProt Splice Variant
Entrez Gene 539235
UniGene Bt.74393
RefSeq NM_001046454
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY881696 BC110170 HE864424 HE864487
GenPept AAI10171 AAY57796 CCI79661 CCI79724
RNA Seq Atlas 539235

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca