Version 5.4
Bos taurus Gene: SENP5
Summary
InnateDB Gene IDBG-634075.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP5
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000032674
Encoded Proteins
IDBP-685847
SUMO1/sentrin specific peptidase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119231:
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:71980544-72010052
Strand Forward strand
Band
Transcripts
ENSBTAT00000046389 ENSBTAP00000043696
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000119231
View Gene Order
ENSMUSG00000022772
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_163793
Processing and activation of SUMO pathway
REACT_17015
Metabolism of proteins pathway
REACT_163725
SUMO is proteolytically processed pathway
REACT_163823
SUMOylation pathway
REACT_196649
SUMO is proteolytically processed pathway
REACT_196652
SUMOylation pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_196651
Processing and activation of SUMO pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MBS6
UniProt Splice Variant
Entrez Gene 100298192
UniGene Bt.87743
RefSeq XM_002684824
HUGO HGNC:28407
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001703 DAAA02001704
GenPept
RNA Seq Atlas 100298192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca