Version 5.4
Bos taurus Gene: MFI2
Summary
InnateDB Gene IDBG-634107.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFI2
Gene Name melanotransferrin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002998
Encoded Proteins
IDBP-685867
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163975:
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:72086119-72109936
Strand Reverse strand
Band
Transcripts
ENSBTAT00000046533 ENSBTAP00000043824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008199 ferric iron binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0010756 positive regulation of plasminogen activation
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0097286 iron ion import
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005576 extracellular region
GO:0009986 cell surface
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163975
View Gene Order
ENSMUSG00000022780
View Gene Order
Cross-References
SwissProt
TrEMBL E1BG25
UniProt Splice Variant
Entrez Gene 539803
UniGene Bt.42115
RefSeq NM_001192312 XM_005201520
HUGO HGNC:7037
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001706
GenPept
RNA Seq Atlas 539803

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca