InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ILK

Summary

InnateDB Gene

IDBG-634121.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ILK

Gene Name

integrin-linked protein kinase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000696

Encoded Proteins

IDBP-685880

integrin-linked protein kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166333:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:47074662-47082065

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000927

ENSBTAP00000000927

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010761	fibroblast migration
GO:0014044	Schwann cell development
GO:0018105	peptidyl-serine phosphorylation
GO:0021675	nerve development
GO:0022011	myelination in peripheral nervous system
GO:0030030	cell projection organization
GO:0030513	positive regulation of BMP signaling pathway
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0043491	protein kinase B signaling
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation