InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ILK

Summary

InnateDB Protein

IDBP-685880.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ILK

Protein Name

integrin-linked protein kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000927

InnateDB Gene

IDBG-634121 (ILK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010761	fibroblast migration
GO:0014044	Schwann cell development
GO:0018105	peptidyl-serine phosphorylation
GO:0021675	nerve development
GO:0022011	myelination in peripheral nervous system
GO:0030030	cell projection organization
GO:0030513	positive regulation of BMP signaling pathway
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0043491	protein kinase B signaling
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016253 Integrin-linked protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

PIRSF000654

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References