InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: COL15A1

Summary

InnateDB Gene

IDBG-634131.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL15A1

Gene Name

collagen alpha-1(XV) chain precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010082

Encoded Proteins

IDBP-685905

collagen, type XV, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204291:
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, Jul 2008]
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:64437276-64540739

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013292

ENSBTAP00000013292

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005581	collagen trimer
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome