InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COL15A1

Summary

InnateDB Gene

IDBG-78445.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL15A1

Gene Name

collagen, type XV, alpha 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000204291

Encoded Proteins

IDBP-78447

collagen, type XV, alpha 1

IDBP-806455

collagen, type XV, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, Jul 2008]
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:98943179-99070792

Strand

Forward strand

Band

q22.33

Transcripts

ENST00000375001	ENSP00000364140
ENST00000467052
ENST00000471477
ENST00000496686
ENST00000610452	ENSP00000483455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005201	extracellular matrix structural constituent

Biological Process

GO:0001525	angiogenesis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0022617	extracellular matrix disassembly
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005582	collagen type XV
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028339

View Gene Order

ENSBTAG00000010082

Not yet available

Pathways

NETPATH

REACTOME

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_121139

Collagen biosynthesis and modifying enzymes pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_120729

Collagen formation pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001855

HUGO

OMIM

CCDS

CCDS35081

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas