InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MTIF2

Summary

InnateDB Gene

IDBG-634134.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTIF2

Gene Name

Translation initiation factor IF-2, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015481

Encoded Proteins

IDBP-685892

Translation initiation factor IF-2, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085760:
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38%% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:37826329-37848931

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020573

ENSBTAP00000020573

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001732	formation of translation initiation complex
GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0007264	small GTPase mediated signal transduction
GO:0032790	ribosome disassembly