InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtif2

Summary

InnateDB Gene

IDBG-157478.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtif2

Gene Name

mitochondrial translational initiation factor 2

Synonyms

2310038D14Rik; 2410112O06Rik; IF-2(Mt); IF-2mt; IF2(mt)

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020459

Encoded Proteins

IDBP-157482

mitochondrial translational initiation factor 2

IDBP-157484

mitochondrial translational initiation factor 2

IDBP-539077

mitochondrial translational initiation factor 2

IDBP-536702

mitochondrial translational initiation factor 2

IDBP-537480

mitochondrial translational initiation factor 2

IDBP-537780

mitochondrial translational initiation factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085760:
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38%% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:29526408-29545279

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000020749	ENSMUSP00000020749
ENSMUST00000093239	ENSMUSP00000090926
ENSMUST00000133452	ENSMUSP00000122233
ENSMUST00000136351	ENSMUSP00000122801
ENSMUST00000156352
ENSMUST00000144321	ENSMUSP00000114299
ENSMUST00000132783	ENSMUSP00000121327
ENSMUST00000129893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001732	formation of translation initiation complex
GO:0006184	GTP catabolic process
GO:0006446	regulation of translational initiation
GO:0007264	small GTPase mediated signal transduction
GO:0008150	biological_process
GO:0032790	ribosome disassembly