InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CACNA1H

Summary

InnateDB Gene

IDBG-634137.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CACNA1H

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026461

Encoded Proteins

IDBP-685972

calcium channel, voltage-dependent, T type, alpha 1H subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196557:
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:959758-984950

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012991

ENSBTAP00000012991

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008332	low voltage-gated calcium channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0032342	aldosterone biosynthetic process
GO:0032870	cellular response to hormone stimulus
GO:0034651	cortisol biosynthetic process
GO:0034765	regulation of ion transmembrane transport
GO:0035865	cellular response to potassium ion
GO:0042391	regulation of membrane potential
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential
GO:2000344	positive regulation of acrosome reaction

Cellular Component

GO:0005886	plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042383	sarcolemma