InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CCDC88A

Summary

InnateDB Gene

IDBG-634141.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCDC88A

Gene Name

girdin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017469

Encoded Proteins

IDBP-685948

coiled-coil domain containing 88A

IDBP-685950

coiled-coil domain containing 88A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21209316

[Homo sapiens] CCDC88A, an activator of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1 and CCDC88A determines whether autophagy is promoted or inhibited. When stimulated by growth factors, CCDC88A disrupts the GNAI3::GPSM1 complex, subsequently enhancing anti-autophagy signalling pathways and inhibits autophagy by activating GNAI3.

PMID 21209316

[Mus musculus] Ccdc88a, an activator of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1 and Ccdc88a determines whether autophagy is promoted or inhibited. When stimulated by growth factors, Ccdc88a disrupts the Gnai3::Gpsm1 complex, subsequently enhancing anti-autophagy signaling pathways and inhibits autophagy by activating Gnai3.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115355:
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:37867045-37981414

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033104	ENSBTAP00000033028
ENSBTAT00000064674	ENSBTAP00000054230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity
GO:0043422	protein kinase B binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006275	regulation of DNA replication
GO:0010975	regulation of neuron projection development
GO:0016477	cell migration
GO:0030032	lamellipodium assembly
GO:0031929	TOR signaling
GO:0032148	activation of protein kinase B activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0042127	regulation of cell proliferation
GO:0061024	membrane organization

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000115355

View Gene Order

ENSMUSG00000032740

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.108587 Bt.26218

RefSeq

NM_001206209 XM_005212639 XM_005212641

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas