Version 5.4
Homo sapiens Gene: CCDC88A
Summary
InnateDB Gene IDBG-52430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC88A
Gene Name coiled-coil domain containing 88A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115355
Encoded Proteins
IDBP-52432
coiled-coil domain containing 88A
IDBP-52434
coiled-coil domain containing 88A
IDBP-376374
coiled-coil domain containing 88A
IDBP-376404
coiled-coil domain containing 88A
IDBP-376414
coiled-coil domain containing 88A
IDBP-376423
coiled-coil domain containing 88A
IDBP-376429
coiled-coil domain containing 88A
IDBP-376435
coiled-coil domain containing 88A
IDBP-376439
coiled-coil domain containing 88A
IDBP-807802
coiled-coil domain containing 88A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21209316
CCDC88A, an activator of GNAI3, plays a key role in regulating autophagy; the dynamic interplay between GNAI3, GPSM1 and CCDC88A determines whether autophagy is promoted or inhibited. When stimulated by growth factors, CCDC88A disrupts the GNAI3::GPSM1 complex, subsequently enhancing anti-autophagy signalling pathways and inhibits autophagy by activating GNAI3.
InnateDB Annotation from Orthologs
Summary
PMID 21209316
[Mus musculus] Ccdc88a, an activator of Gnai3, plays a key role in regulating autophagy; the dynamic interplay between Gnai3, Gpsm1 and Ccdc88a determines whether autophagy is promoted or inhibited. When stimulated by growth factors, Ccdc88a disrupts the Gnai3::Gpsm1 complex, subsequently enhancing anti-autophagy signaling pathways and inhibits autophagy by activating Gnai3.
Entrez Gene
Summary This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:55287842-55419921
Strand Reverse strand
Band p16.1
Transcripts
ENST00000336838 ENSP00000338728
ENST00000263630 ENSP00000263630
ENST00000436346 ENSP00000410608
ENST00000413716 ENSP00000404431
ENST00000444458 ENSP00000413401
ENST00000412148 ENSP00000390012
ENST00000426576 ENSP00000405080
ENST00000456975 ENSP00000415267
ENST00000430086 ENSP00000399237
ENST00000474059
ENST00000476903
ENST00000468534
ENST00000471947
ENST00000621814 ENSP00000480931
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0035091 phosphatidylinositol binding
GO:0042803 protein homodimerization activity
GO:0043422 protein kinase B binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0010975 regulation of neuron projection development
GO:0016192 vesicle-mediated transport
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0031929 TOR signaling
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0042127 regulation of cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0061024 membrane organization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032740
View Gene Order
ENSBTAG00000017469
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292925 Hs.607733 Hs.608481 Hs.614508 Hs.620023
RefSeq NM_001135597 NM_001254943 NM_018084 XM_005264423 XM_005264426 XM_005264427
HUGO
OMIM
CCDS CCDS33203 CCDS46288 CCDS58710
HPRD 11131
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca