Version 5.4
Bos taurus Gene: DDX39B
Summary
InnateDB Gene IDBG-634185.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX39B
Gene Name Spliceosome RNA helicase DDX39B
Synonyms BAT1
Species Bos taurus
Ensembl Gene ENSBTAG00000014490
Encoded Proteins
IDBP-685955
Spliceosome RNA helicase DDX39B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198563:
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27565924-27576711
Strand Forward strand
Band
Transcripts
ENSBTAT00000029090 ENSBTAP00000029090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008186 RNA-dependent ATPase activity
GO:0016787 hydrolase activity
GO:0017070 U6 snRNA binding
GO:0030621 U4 snRNA binding
GO:0043008 ATP-dependent protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006200 ATP catabolic process
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0006810 transport
GO:0008380 RNA splicing
GO:0010501 RNA secondary structure unwinding
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0046784 intronless viral mRNA export from host nucleus
GO:0051028 mRNA transport
GO:2000002 negative regulation of DNA damage checkpoint
Cellular Component
GO:0000346 transcription export complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005687 U4 snRNP
GO:0005688 U6 snRNP
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198563
View Gene Order
ENSMUSG00000019432
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03040
Spliceosome pathway
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
mmu03040
Spliceosome pathway
mmu03013
RNA transport pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q3T147
TrEMBL Q861P7
UniProt Splice Variant
Entrez Gene 540191
UniGene Bt.4945
RefSeq NM_001033629
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF158723 BC102131
GenPept AAI02132 AAO25754
RNA Seq Atlas 540191

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca