Version 5.4
Bos taurus Gene: OPA1
Summary
InnateDB Gene IDBG-634327.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPA1
Gene Name dynamin-like 120 kDa protein, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019514
Encoded Proteins
IDBP-686111
optic atrophy 1 (autosomal dominant)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198836:
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74383828-74467298
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026013 ENSBTAP00000026013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0001843 neural tube closure
GO:0006184 GTP catabolic process
GO:0007007 inner mitochondrial membrane organization
GO:0007601 visual perception
GO:0008053 mitochondrial fusion
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090398 cellular senescence
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0016020 membrane
GO:0030061 mitochondrial crista
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198836
View Gene Order
ENSMUSG00000038084
View Gene Order
Cross-References
SwissProt
TrEMBL E1BBC4
UniProt Splice Variant
Entrez Gene 524142
UniGene Bt.12096
RefSeq NM_001192961
HUGO HGNC:8140
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001740
GenPept
RNA Seq Atlas 524142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca