Version 5.4
Mus musculus Gene: Opa1
Summary
InnateDB Gene IDBG-151468.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Opa1
Gene Name optic atrophy 1
Synonyms 1200011N24Rik; AI225888; AI847218; lilr3; mKIAA0567
Species Mus musculus
Ensembl Gene ENSMUSG00000038084
Encoded Proteins
IDBP-151470
optic atrophy 1 homolog (human)
IDBP-537807
optic atrophy 1 homolog (human)
IDBP-535317
optic atrophy 1 homolog (human)
IDBP-536023
optic atrophy 1 homolog (human)
IDBP-537063
optic atrophy 1 homolog (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198836:
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:29579334-29654884
Strand Forward strand
Band B2
Transcripts
ENSMUST00000038867 ENSMUSP00000036993
ENSMUST00000160597 ENSMUSP00000124223
ENSMUST00000159036
ENSMUST00000160475 ENSMUSP00000124739
ENSMUST00000161186 ENSMUSP00000123880
ENSMUST00000160153
ENSMUST00000162240 ENSMUSP00000124029
ENSMUST00000160101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0001843 neural tube closure
GO:0006184 GTP catabolic process
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007007 inner mitochondrial membrane organization
GO:0007601 visual perception
GO:0008053 mitochondrial fusion
GO:0050896 response to stimulus
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090398 cellular senescence
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030061 mitochondrial crista
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198836
View Gene Order
ENSBTAG00000019514
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.397059 Mm.421980
RefSeq NM_001199177 NM_133752
OMIM
CCDS CCDS28096 CCDS57024
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca