Version 5.4
Bos taurus Gene: LEPREL1
Summary
InnateDB Gene IDBG-634523.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LEPREL1
Gene Name prolyl 3-hydroxylase 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021025
Encoded Proteins
IDBP-686311
prolyl 3-hydroxylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090530:
This gene encodes a member of the prolyl 3-hydroxylase subfamily of 2-oxo-glutarate-dependent dioxygenases. These enzymes play a critical role in collagen chain assembly, stability and cross-linking by catalyzing post-translational 3-hydroxylation of proline residues. Mutations in this gene are associated with nonsyndromic severe myopia with cataract and vitreoretinal degeneration, and downregulation of this gene may play a role in breast cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77752546-77932253
Strand Forward strand
Band
Transcripts
ENSBTAT00000027999 ENSBTAP00000027999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019797 procollagen-proline 3-dioxygenase activity
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0008285 negative regulation of cell proliferation
GO:0019511 peptidyl-proline hydroxylation
GO:0032963 collagen metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005604 basement membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000090530
View Gene Order
ENSMUSG00000038168
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
REACT_199045
Collagen formation pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_206066
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A6QLY3
UniProt Splice Variant
Entrez Gene 511799
UniGene Bt.30683
RefSeq NM_001100345 XM_005201471 XM_005201472
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148129 DAAA02001802 DAAA02001803
GenPept AAI48130
RNA Seq Atlas 511799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca