Version 5.4
Bos taurus Gene: CASQ2
Summary
InnateDB Gene IDBG-634546.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASQ2
Gene Name calsequestrin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011500
Encoded Proteins
IDBP-686325
calsequestrin 2 (cardiac muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118729:
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:27658862-27729416
Strand Forward strand
Band
Transcripts
ENSBTAT00000015285 ENSBTAP00000015285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0002027 regulation of heart rate
GO:0010649 regulation of cell communication by electrical coupling
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0043267 negative regulation of potassium ion transport
GO:0051208 sequestering of calcium ion
GO:0051258 protein polymerization
GO:0060048 cardiac muscle contraction
GO:0060306 regulation of membrane repolarization
GO:0071313 cellular response to caffeine
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0030018 Z disc
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000118729
View Gene Order
ENSMUSG00000027861
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q3MHM1
UniProt Splice Variant
Entrez Gene 528555
UniGene Bt.30022
RefSeq NM_001035374
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105185 DAAA02007427 DAAA02007428
GenPept AAI05186
RNA Seq Atlas 528555

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca