Version 5.4
Bos taurus Gene: MTHFD1L
Summary
InnateDB Gene IDBG-634564.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFD1L
Gene Name monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009846
Encoded Proteins
IDBP-686368
monofunctional C1-tetrahydrofolate synthase, mitochondrial precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120254:
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:89136756-89267192
Strand Forward strand
Band
Transcripts
ENSBTAT00000052076 ENSBTAP00000052260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120254
View Gene Order
ENSMUSG00000040675
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
mmu00670
One carbon pool by folate pathway
INOH
INOH website
Folate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL E1B884
UniProt Splice Variant
Entrez Gene 534296
UniGene Bt.7490
RefSeq NM_001076018
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02027149 DAAA02027150
GenPept
RNA Seq Atlas 534296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca