Version 5.4
Mus musculus Gene: Mthfd1l
Summary
InnateDB Gene IDBG-131984.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mthfd1l
Gene Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040675
Encoded Proteins
IDBP-131986
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
IDBP-401720
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
IDBP-401719
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120254:
The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:3973118-4167081
Strand Forward strand
Band A1
Transcripts
ENSMUST00000043735 ENSMUSP00000036178
ENSMUST00000120585 ENSMUSP00000112897
ENSMUST00000117291 ENSMUSP00000112870
ENSMUST00000154517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0009257 10-formyltetrahydrofolate biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0015942 formate metabolic process
GO:0035999 tetrahydrofolate interconversion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120254
View Gene Order
ENSBTAG00000009846
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00670
One carbon pool by folate pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00670
One carbon pool by folate pathway
INOH
INOH website
Folate metabolism pathway
PID NCI
Cross-References
SwissProt Q3V3R1
TrEMBL
UniProt Splice Variant
Entrez Gene 270685
UniGene Mm.184752 Mm.398903
RefSeq NM_001170786 NM_001170785 NM_172308
OMIM
CCDS CCDS56672
HPRD
IMGT
MGI ID MGI:1924836
MGI Symbol Mthfd1l
EMBL AK028211 AK036284 AK038579 AK160025 BC030437 BC049936
GenPept AAH30437 AAH49936 BAC30053 BAE20438 BAE20500 BAE35568
RNA Seq Atlas 270685

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca