InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: YY1

Summary

InnateDB Gene

IDBG-634606.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YY1

Gene Name

transcriptional repressor protein YY1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020819

Encoded Proteins

IDBP-686381

transcriptional repressor protein YY1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22065573

[Homo sapiens] YY1 negatively regulates TLR3-induced expression of IFN-beta and acts downstream of TLR3 to limit the level and duration of anti-viral response.

PMID 22065573

[Mus musculus] Yy1 negatively regulates TLR3-induced expression of IFN-beta and acts downstream of TLR3 to limit the level and duration of the anti-viral response. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100811:
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:66817739-66842006

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027744

ENSBTAP00000027744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000724	double-strand break repair via homologous recombination
GO:0006355	regulation of transcription, DNA-templated
GO:0006403	RNA localization
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0009952	anterior/posterior pattern specification
GO:0010225	response to UV-C
GO:0034644	cellular response to UV
GO:0048593	camera-type eye morphogenesis
GO:0051276	chromosome organization