Version 5.4
Bos taurus Gene: KNG1
Summary
InnateDB Gene IDBG-634652.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KNG1
Gene Name Kininogen-1 Kininogen-1 heavy chain Bradykinin Lysyl-bradykinin Kininogen-1 light chain
Synonyms KNG; KNG2
Species Bos taurus
Ensembl Gene ENSBTAG00000005122
Encoded Proteins
IDBP-686444
kininogen-1 isoform I
IDBP-686447
kininogen-1 isoform I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:81097435-81121112
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006755 ENSBTAP00000006755
ENSBTAT00000053071 ENSBTAP00000048995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007162 negative regulation of cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030195 negative regulation of blood coagulation
GO:0042311 vasodilation
GO:0045861 negative regulation of proteolysis
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_219025
Peptide ligand-binding receptors pathway
REACT_205369
Signaling by GPCR pathway
REACT_206454
Intrinsic Pathway pathway
REACT_212196
Hemostasis pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_210568
G alpha (i) signalling events pathway
REACT_214353
Signal Transduction pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_220217
GPCR ligand binding pathway
REACT_208412
Class A/1 (Rhodopsin-like receptors) pathway
REACT_217138
Formation of Fibrin Clot (Clotting Cascade) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4210
RefSeq NM_001113277 NM_175774 XM_005201452
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca