InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KNG1

Summary

InnateDB Protein

IDBP-686447.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KNG1

Protein Name

kininogen-1 isoform I

Synonyms

KNG; KNG2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000048995

InnateDB Gene

IDBG-634652 (KNG1)

Protein Structure

UniProt Annotation

Function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity

Biological Process

GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007162	negative regulation of cell adhesion
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0010466	negative regulation of peptidase activity
GO:0010951	negative regulation of endopeptidase activity
GO:0030195	negative regulation of blood coagulation
GO:0042311	vasodilation
GO:0045861	negative regulation of proteolysis
GO:0050880	regulation of blood vessel size

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR000010 Proteinase inhibitor I25, cystatin
IPR001894 Cathelicidin
IPR002395 HMW kininogen

PFAM

PF00031
PF00666

PRINTS

PR00334

PIRSF

SMART

SM00043

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01044

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280833

UniGene

Bt.4210

RefSeq

NP_786968

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105499 V00426 V01491

GenPept

AAI05500 CAA23709 CAA24735