InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HRG

Summary

InnateDB Gene

IDBG-634671.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRG

Gene Name

histidine-rich glycoprotein precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001265

Encoded Proteins

IDBP-686456

histidine-rich glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21757718

[Homo sapiens] HRG binds fibrinogen with high affinity and competes with thrombin for binding. This interaction may provide a novel link between coagulation, innate immunity and inflammation.

PMID 21757718

[Mus musculus] Hrg binds fibrinogen with high affinity and competes with thrombin for binding. This interaction may provide a novel link between coagulation, innate immunity and inflammation. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113905:
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008]
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein\'s effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:81127291-81135756

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001667

ENSBTAP00000001667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding
GO:0019865	immunoglobulin binding
GO:0020037	heme binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046872	metal ion binding

Biological Process

GO:0002839	positive regulation of immune response to tumor cell
GO:0007162	negative regulation of cell adhesion
GO:0008285	negative regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010543	regulation of platelet activation
GO:0010593	negative regulation of lamellipodium assembly
GO:0010951	negative regulation of endopeptidase activity
GO:0014070	response to organic cyclic compound
GO:0015886	heme transport
GO:0016525	negative regulation of angiogenesis
GO:0030168	platelet activation
GO:0030193	regulation of blood coagulation
GO:0030308	negative regulation of cell growth
GO:0032956	regulation of actin cytoskeleton organization
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron
GO:0043065	positive regulation of apoptotic process
GO:0043254	regulation of protein complex assembly
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050832	defense response to fungus
GO:0051894	positive regulation of focal adhesion assembly
GO:0051918	negative regulation of fibrinolysis
GO:0097037	heme export
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
GO:2000504	positive regulation of blood vessel remodeling
GO:2001027	negative regulation of endothelial cell chemotaxis