Version 5.4
Bos taurus Protein: HRG
Summary
InnateDB Protein IDBP-686456.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRG
Protein Name histidine-rich glycoprotein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001667
InnateDB Gene IDBG-634671 (HRG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0019865 immunoglobulin binding
GO:0020037 heme binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0046872 metal ion binding
Biological Process
GO:0002839 positive regulation of immune response to tumor cell
GO:0007162 negative regulation of cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0010468 regulation of gene expression
GO:0010543 regulation of platelet activation
GO:0010593 negative regulation of lamellipodium assembly
GO:0010951 negative regulation of endopeptidase activity
GO:0014070 response to organic cyclic compound
GO:0015886 heme transport
GO:0016525 negative regulation of angiogenesis
GO:0030168 platelet activation
GO:0030193 regulation of blood coagulation
GO:0030308 negative regulation of cell growth
GO:0032956 regulation of actin cytoskeleton organization
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron
GO:0043065 positive regulation of apoptotic process
GO:0043254 regulation of protein complex assembly
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050832 defense response to fungus
GO:0051894 positive regulation of focal adhesion assembly
GO:0051918 negative regulation of fibrinolysis
GO:0097037 heme export
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:2000504 positive regulation of blood vessel remodeling
GO:2001027 negative regulation of endothelial cell chemotaxis
Cellular Component
GO:0031982 vesicle
GO:0036019 endolysosome
GO:0061474 phagolysosome membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MKS5
UniProt Splice Variant
Entrez Gene 280820
UniGene Bt.107250
RefSeq NP_776344
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001848
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca