InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EIF2AK3

Summary

InnateDB Gene

IDBG-634760.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2AK3

Gene Name

eukaryotic translation initiation factor 2-alpha kinase 3 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000184

Encoded Proteins

IDBP-686556

eukaryotic translation initiation factor 2-alpha kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172071:
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:47302536-47384700

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000210

ENSBTAP00000000210

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0002063	chondrocyte development
GO:0006412	translation
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983	ER overload response
GO:0007029	endoplasmic reticulum organization
GO:0007595	lactation
GO:0009967	positive regulation of signal transduction
GO:0010629	negative regulation of gene expression
GO:0017148	negative regulation of translation
GO:0019217	regulation of fatty acid metabolic process
GO:0019722	calcium-mediated signaling
GO:0030282	bone mineralization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031016	pancreas development
GO:0031018	endocrine pancreas development
GO:0031642	negative regulation of myelination
GO:0032092	positive regulation of protein binding
GO:0032933	SREBP signaling pathway
GO:0034976	response to endoplasmic reticulum stress
GO:0043066	negative regulation of apoptotic process
GO:0045444	fat cell differentiation
GO:0046777	protein autophosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress