Version 5.4
Bos taurus Protein: EIF2AK3
Summary
InnateDB Protein IDBP-686556.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK3
Protein Name eukaryotic translation initiation factor 2-alpha kinase 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000210
InnateDB Gene IDBG-634760 (EIF2AK3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0002063 chondrocyte development
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 ER overload response
GO:0007029 endoplasmic reticulum organization
GO:0007595 lactation
GO:0009967 positive regulation of signal transduction
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0019217 regulation of fatty acid metabolic process
GO:0019722 calcium-mediated signaling
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031642 negative regulation of myelination
GO:0032092 positive regulation of protein binding
GO:0032933 SREBP signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D791
UniProt Splice Variant
Entrez Gene 535820
UniGene Bt.58192
RefSeq NP_001091555
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140471 DAAA02031107 DAAA02031108
GenPept AAI40472

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca