Version 5.4
Bos taurus Gene: BT.78411
Summary
InnateDB Gene IDBG-634830.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.78411
Gene Name mitogen-activated protein kinase kinase kinase 13
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017103
Encoded Proteins
IDBP-686631
mitogen-activated protein kinase kinase kinase 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073803:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:82301321-82426795
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022739 ENSBTAP00000022739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0016310 phosphorylation
GO:0046777 protein autophosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0008385 IkappaB kinase complex
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000073803
View Gene Order
ENSMUSG00000033618
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MGX2
UniProt Splice Variant
Entrez Gene 505369
UniGene Bt.78411
RefSeq NM_001101853
HUGO HGNC:6852
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001859 DAAA02001860 DAAA02001861 DAAA02001862 DAAA02001863
GenPept
RNA Seq Atlas 505369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca