Version 5.4
Homo sapiens Gene: MAP3K13
Summary
InnateDB Gene IDBG-68473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP3K13
Gene Name mitogen-activated protein kinase kinase kinase 13
Synonyms LZK; MEKK13; MLK
Species Homo sapiens
Ensembl Gene ENSG00000073803
Encoded Proteins
IDBP-68475
mitogen-activated protein kinase kinase kinase 13
IDBP-386240
mitogen-activated protein kinase kinase kinase 13
IDBP-386242
mitogen-activated protein kinase kinase kinase 13
IDBP-386244
mitogen-activated protein kinase kinase kinase 13
IDBP-386245
mitogen-activated protein kinase kinase kinase 13
IDBP-386246
mitogen-activated protein kinase kinase kinase 13
IDBP-386247
mitogen-activated protein kinase kinase kinase 13
IDBP-386248
mitogen-activated protein kinase kinase kinase 13
IDBP-386249
mitogen-activated protein kinase kinase kinase 13
IDBP-386250
mitogen-activated protein kinase kinase kinase 13
IDBP-386252
mitogen-activated protein kinase kinase kinase 13
IDBP-386255
mitogen-activated protein kinase kinase kinase 13
IDBP-386257
mitogen-activated protein kinase kinase kinase 13
IDBP-386259
mitogen-activated protein kinase kinase kinase 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:185282941-185489097
Strand Forward strand
Band q27.2
Transcripts
ENST00000265026 ENSP00000265026
ENST00000448876 ENSP00000392223
ENST00000446828 ENSP00000411483
ENST00000455188 ENSP00000405233
ENST00000447637 ENSP00000389495
ENST00000424227 ENSP00000399910
ENST00000454237 ENSP00000412037
ENST00000438798 ENSP00000390323
ENST00000428617 ENSP00000405163
ENST00000443863 ENSP00000409325
ENST00000433092 ENSP00000389798
ENST00000438053 ENSP00000403561
ENST00000439882 ENSP00000407361
ENST00000420577 ENSP00000415712
ENST00000477582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0046777 protein autophosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0008385 IkappaB kinase complex
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033618
View Gene Order
ENSBTAG00000017103
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL C9JP65
UniProt Splice Variant
Entrez Gene 9175
UniGene Hs.591306 Hs.634586 Hs.656069 Hs.665971 Hs.715977
RefSeq NM_001242314 NM_001242317 NM_004721
HUGO HGNC:6852
OMIM 604915
CCDS CCDS3270 CCDS56298
HPRD 05372
IMGT
EMBL AC099661 AC128680 AC132516
GenPept
RNA Seq Atlas 9175

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca