Version 5.4
Bos taurus Gene: PTPN22
Summary
InnateDB Gene IDBG-634891.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN22
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019617
Encoded Proteins
IDBP-686688
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134242:
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:29666149-29722631
Strand Forward strand
Band
Transcripts
ENSBTAT00000026136 ENSBTAP00000026136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0030217 T cell differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134242
View Gene Order
ENSMUSG00000027843
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N6L3
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:9652
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007480 DAAA02007481
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca