Version 5.4
Homo sapiens Gene: PTPN22
Summary
InnateDB Gene IDBG-101222.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN22
Gene Name protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134242
Encoded Proteins
IDBP-101226
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-387810
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-597360
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-592333
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-587252
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-586506
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-597246
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
IDBP-601630
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:113813811-113871759
Strand Reverse strand
Band p13.2
Transcripts
ENST00000359785 ENSP00000352833
ENST00000420377 ENSP00000388229
ENST00000460620 ENSP00000433141
ENST00000469077
ENST00000484147
ENST00000528414 ENSP00000435176
ENST00000532224 ENSP00000431249
ENST00000525799 ENSP00000432674
ENST00000534519
ENST00000529045 ENSP00000434932
ENST00000538253 ENSP00000439372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
GO:0019900 kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0030217 T cell differentiation
GO:0032817 regulation of natural killer cell proliferation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035644 phosphoanandamide dephosphorylation
GO:0045088 regulation of innate immune response
GO:0050852 T cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027843
View Gene Order
ENSBTAG00000019617
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.535276
RefSeq NM_001193431 NM_012411 NM_015967 XM_005270738
HUGO
OMIM
CCDS CCDS863 CCDS864
HPRD 06100
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca