InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.64620

Summary

InnateDB Gene

IDBG-634914.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.64620

Gene Name

DNA-directed RNA polymerase II subunit RPB1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046765

Encoded Proteins

IDBP-686791

DNA-directed RNA polymerase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181222:
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:27786959-27814917

Strand

Forward strand

Band

Transcripts

ENSBTAT00000064788

ENSBTAP00000055142

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 217 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	217 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001055	RNA polymerase II activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity