Version 5.4
Homo sapiens Gene: POLR2A
Summary
InnateDB Gene IDBG-25255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2A
Gene Name polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Synonyms hRPB220; hsRPB1; POLR2; POLRA; RPB1; RPBh1; RpIILS; RPO2; RPOL2
Species Homo sapiens
Ensembl Gene ENSG00000181222
Encoded Proteins
IDBP-762613
IDBP-812578
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
IDBP-812591
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7484366-7514618
Strand Forward strand
Band p13.1
Transcripts
ENST00000576718
ENST00000576952
ENST00000573603
ENST00000572844 ENSP00000461879
ENST00000575547
ENST00000576553
ENST00000576114
ENST00000574158
ENST00000617998 ENSP00000480158
ENST00000621442 ENSP00000483957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 435 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 435 [view]
Protein-Protein 304 [view]
Protein-DNA 131 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005198
View Gene Order
ENSBTAG00000046765
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5430
UniGene
RefSeq NM_000937
HUGO HGNC:9187
OMIM 180660
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 102723646 5430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca