InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.104940

Summary

InnateDB Gene

IDBG-634926.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.104940

Gene Name

hepatocyte nuclear factor 1-alpha

Synonyms

HNF-1a

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021795

Encoded Proteins

IDBP-686719

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135100:
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. [provided by RefSeq, Mar 2009]
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5\'-GTTAATNATTAAC-3\'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:65417479-65434194

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029049

ENSBTAP00000029049

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 217 interaction(s) predicted by orthology.

Predicted by orthology
Total	217 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0001824	blastocyst development
GO:0001889	liver development
GO:0001890	placenta development
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006633	fatty acid biosynthetic process
GO:0006699	bile acid biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006979	response to oxidative stress
GO:0008104	protein localization
GO:0008203	cholesterol metabolic process
GO:0009749	response to glucose
GO:0015721	bile acid and bile salt transport
GO:0015908	fatty acid transport
GO:0030073	insulin secretion
GO:0030111	regulation of Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0031018	endocrine pancreas development
GO:0035623	renal glucose absorption
GO:0042593	glucose homeostasis
GO:0043691	reverse cholesterol transport
GO:0045453	bone resorption
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046323	glucose import
GO:0046883	regulation of hormone secretion
GO:0048341	paraxial mesoderm formation
GO:0048608	reproductive structure development
GO:0050796	regulation of insulin secretion
GO:0060395	SMAD protein signal transduction