Version 5.4
Mus musculus Gene: Hnf1a
Summary
InnateDB Gene IDBG-193173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnf1a
Gene Name HNF1 homeobox A
Synonyms AI323641; Hnf-1; HNF1; HNF1-alpha; HNF1[a]; Hnf1alpha; LFB1; Tcf-1; Tcf1
Species Mus musculus
Ensembl Gene ENSMUSG00000029556
Encoded Proteins
IDBP-193175
HNF1 homeobox A
IDBP-725060
IDBP-724910
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114948980-114971094
Strand Reverse strand
Band F
Transcripts
ENSMUST00000031535 ENSMUSP00000031535
ENSMUST00000176911 ENSMUSP00000135539
ENSMUST00000176550 ENSMUSP00000135678
ENSMUST00000184027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 230 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 230 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001221 transcription cofactor binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001824 blastocyst development
GO:0001889 liver development
GO:0001890 placenta development
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006633 fatty acid biosynthetic process
GO:0006699 bile acid biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006979 response to oxidative stress
GO:0008104 protein localization
GO:0008203 cholesterol metabolic process
GO:0009749 response to glucose
GO:0015721 bile acid and bile salt transport
GO:0015908 fatty acid transport
GO:0030073 insulin secretion
GO:0030111 regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0031018 endocrine pancreas development
GO:0035623 renal glucose absorption
GO:0042593 glucose homeostasis
GO:0043691 reverse cholesterol transport
GO:0045453 bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046323 glucose import
GO:0046883 regulation of hormone secretion
GO:0048341 paraxial mesoderm formation
GO:0048608 reproductive structure development
GO:0050796 regulation of insulin secretion
GO:0060395 SMAD protein signal transduction
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0045120 pronucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135100
View Gene Order
ENSBTAG00000021795
Not yet available
Pathways
NETPATH
REACTOME
REACT_214529
Regulation of gene expression in beta cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
KEGG
mmu04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_18
IL6 pathway
REACTOME
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
ps1pathway
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.332607
RefSeq NM_009327
OMIM
CCDS CCDS19577
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca