Version 5.4
| Bos taurus Gene: BT.60810 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-634943.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | BT.60810 | ||||||||||||||||||
| Gene Name | G1/S-specific cyclin-E1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000004735 | ||||||||||||||||||
| Encoded Proteins |
Uncharacterized protein
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105173:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 18:40565286-40574820 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH |
AndrogenReceptor pathway
TGF_beta_Receptor pathway
BCR pathway
IL2 pathway
TSH pathway
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| REACTOME |
p53-Dependent G1 DNA Damage Response pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
E2F mediated regulation of DNA replication pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
Cell Cycle, Mitotic pathway
G1/S DNA Damage Checkpoints pathway
Cell Cycle Checkpoints pathway
Cell Cycle, Mitotic pathway
Cellular responses to stress pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
DNA Damage/Telomere Stress Induced Senescence pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cellular Senescence pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
G1/S-Specific Transcription pathway
E2F mediated regulation of DNA replication pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S Phase pathway
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| KEGG |
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Oocyte meiosis pathway
p53 signaling pathway pathway
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
Pathways in cancer pathway
Oocyte meiosis pathway
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| INOH | |||||||||||||||||||
| PID NCI |
PLK3 signaling events
Regulation of retinoblastoma protein
mTOR signaling pathway
E2F transcription factor network
Signaling events mediated by PRL
BARD1 signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Bt.60810 | ||||||||||||||||||
| RefSeq | NM_001192776 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||