Version 5.4
Mus musculus Gene: Ccne1
Summary
InnateDB Gene IDBG-175446.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccne1
Gene Name cyclin E1
Synonyms AW538188; CycE1
Species Mus musculus
Ensembl Gene ENSMUSG00000002068
Encoded Proteins
IDBP-265403
cyclin E1
IDBP-534051
cyclin E1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105173:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:38097984-38107534
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000108023 ENSMUSP00000103658
ENSMUST00000128785
ENSMUST00000137097
ENSMUST00000130329 ENSMUSP00000117662
ENSMUST00000124979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006270 DNA replication initiation
GO:0006468 protein phosphorylation
GO:0016055 Wnt signaling pathway
GO:0045859 regulation of protein kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105173
View Gene Order
ENSBTAG00000004735
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_188957
Cellular responses to stress pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_199110
G0 and Early G1 pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_257943
p53-Dependent G1 DNA Damage Response pathway
REACT_254524
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_219010
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
REACT_188820
Cellular Senescence pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_220647
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_253623
S Phase pathway
KEGG
mmu04115
p53 signaling pathway pathway
mmu04110
Cell cycle pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05200
Pathways in cancer pathway
mmu04114
Oocyte meiosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_14
IL2 pathway
NetPath_23
TSH pathway
REACTOME
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_308
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_120956
Cellular responses to stress pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
plk3_pathway
PLK3 signaling events
rb_1pathway
Regulation of retinoblastoma protein
mtor_4pathway
mTOR signaling pathway
e2f_pathway
E2F transcription factor network
prlsignalingeventspathway
Signaling events mediated by PRL
bard1pathway
BARD1 signaling events
Cross-References
SwissProt Q61457
TrEMBL D3Z3N8
UniProt Splice Variant
Entrez Gene 12447
UniGene Mm.16110 Mm.413361
RefSeq NM_007633
OMIM
CCDS CCDS39914
HPRD
IMGT
MGI ID MGI:88316
MGI Symbol Ccne1
EMBL AC166334 BC062152 BC084588 BC106191 X75888
GenPept AAH62152 AAH84588 AAI06192 CAA53482
RNA Seq Atlas 12447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca