Version 5.4
Bos taurus Gene: CHRD
Summary
InnateDB Gene IDBG-634990.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRD
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002878
Encoded Proteins
IDBP-686842
chordin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090539:
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:83416532-83425904
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045854 ENSBTAP00000043209
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0045545 syndecan binding
Biological Process
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001702 gastrulation with mouth forming second
GO:0001707 mesoderm formation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0007389 pattern specification process
GO:0007417 central nervous system development
GO:0009953 dorsal/ventral pattern formation
GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0045668 negative regulation of osteoblast differentiation
GO:0045785 positive regulation of cell adhesion
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000090539
View Gene Order
ENSMUSG00000006958
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt
TrEMBL F1MG93
UniProt Splice Variant
Entrez Gene 509942
UniGene Bt.1991
RefSeq XM_001788437 XM_002684892
HUGO HGNC:1949
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02001882
GenPept
RNA Seq Atlas 509942

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca