InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHRD

Summary

InnateDB Gene

IDBG-68217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRD

Gene Name

chordin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000090539

Encoded Proteins

IDBP-68219

chordin

IDBP-68221

chordin

IDBP-68223

chordin

IDBP-386188

chordin

IDBP-386189

chordin

IDBP-386192

chordin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:184380073-184390736

Strand

Forward strand

Band

q27.1

Transcripts

ENST00000204604	ENSP00000204604
ENST00000348986	ENSP00000334036
ENST00000356534	ENSP00000348930
ENST00000448472	ENSP00000408624
ENST00000420973	ENSP00000392794
ENST00000450923	ENSP00000408972
ENST00000460627
ENST00000470150
ENST00000496527
ENST00000459711
ENST00000485883
ENST00000482805
ENST00000486066
ENST00000461684
ENST00000482014
ENST00000461120
ENST00000464833

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0019955	cytokine binding
GO:0045545	syndecan binding

Biological Process

GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001702	gastrulation with mouth forming second
GO:0001707	mesoderm formation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0009953	dorsal/ventral pattern formation
GO:0021919	BMP signaling pathway involved in spinal cord dorsal/ventral patterning
GO:0030336	negative regulation of cell migration
GO:0030514	negative regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0033504	floor plate development
GO:0045668	negative regulation of osteoblast differentiation
GO:0045785	positive regulation of cell adhesion

Cellular Component

GO:0005615

extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000006958

View Gene Order

ENSBTAG00000002878

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04350

TGF-beta signaling pathway pathway

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.166186

RefSeq

NM_003741 XM_005247850

HUGO

OMIM

CCDS

CCDS3266

HPRD

04592

IMGT

EMBL

GenPept

RNA Seq Atlas