Version 5.4
Homo sapiens Gene: FUZ
Summary
InnateDB Gene IDBG-63503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUZ
Gene Name fuzzy homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000010361
Encoded Proteins
IDBP-63505
fuzzy homolog (Drosophila)
IDBP-63507
fuzzy homolog (Drosophila)
IDBP-590305
fuzzy homolog (Drosophila)
IDBP-602814
fuzzy homolog (Drosophila)
IDBP-603231
fuzzy homolog (Drosophila)
IDBP-595259
fuzzy homolog (Drosophila)
IDBP-585655
fuzzy homolog (Drosophila)
IDBP-597405
fuzzy homolog (Drosophila)
IDBP-764174
IDBP-766038
IDBP-585267
fuzzy homolog (Drosophila)
IDBP-761768
IDBP-760313
IDBP-765021
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49806869-49817376
Strand Reverse strand
Band q13.33
Transcripts
ENST00000377092 ENSP00000366296
ENST00000313777 ENSP00000313309
ENST00000525130 ENSP00000433492
ENST00000528094 ENSP00000435177
ENST00000533418 ENSP00000431731
ENST00000529634 ENSP00000432148
ENST00000525370 ENSP00000431420
ENST00000534138
ENST00000527973
ENST00000528043 ENSP00000431388
ENST00000531017
ENST00000527585 ENSP00000470863
ENST00000534008
ENST00000529302 ENSP00000471793
ENST00000526575 ENSP00000433164
ENST00000525800 ENSP00000471319
ENST00000527111 ENSP00000469856
ENST00000526435 ENSP00000470155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001736 establishment of planar polarity
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0008285 negative regulation of cell proliferation
GO:0008589 regulation of smoothened signaling pathway
GO:0010172 embryonic body morphogenesis
GO:0015031 protein transport
GO:0021513 spinal cord dorsal/ventral patterning
GO:0030336 negative regulation of cell migration
GO:0035058 nonmotile primary cilium assembly
GO:0042384 cilium assembly
GO:0045724 positive regulation of cilium assembly
GO:0048704 embryonic skeletal system morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090301 negative regulation of neural crest formation
GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000011658
View Gene Order
ENSBTAG00000019183
Not yet available
Pathways
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QZY8
UniProt Splice Variant
Entrez Gene 80199
UniGene
RefSeq NM_001171937 NM_025129 XM_006723397 XM_006723398 XM_006723400
HUGO HGNC:26219
OMIM 610622
CCDS CCDS12781 CCDS54293
HPRD 08662
IMGT
EMBL AC006942
GenPept
RNA Seq Atlas 80199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca