InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUZ

Summary

InnateDB Protein

IDBP-602814.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUZ

Protein Name

fuzzy homolog (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000435177

InnateDB Gene

IDBG-63503 (FUZ)

Protein Structure

UniProt Annotation

Function

Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001736	establishment of planar polarity
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0008285	negative regulation of cell proliferation
GO:0008589	regulation of smoothened signaling pathway
GO:0010172	embryonic body morphogenesis
GO:0015031	protein transport
GO:0030336	negative regulation of cell migration
GO:0035058	nonmotile primary cilium assembly
GO:0042384	cilium assembly
GO:0045724	positive regulation of cilium assembly
GO:0048704	embryonic skeletal system morphogenesis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090301	negative regulation of neural crest formation
GO:2000314	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation